The Babu Lab is located at the newly constructed Research and Innovation Centre at the University of Regina Campus, Saskatchewan.
The primary research focus of Babu’s laboratory is to characterize the comprehensive networks of physical (protein-protein) and functional (gene-gene, or genetic) interaction maps that underlie major cellular processes in prokaryotes and eukaryotes. The resulting physical and functional interaction maps will be integrated to organize protein complexes into higher order pathways that mediate and coordinate major bioprocesses in the cell. The knowledge gained from these interaction maps will not only enhance the fundamental understanding of the molecular wiring of proteins in the cells, but also provide mechanistic insights that could be potentially exploited for identifying novel therapeutic targets as well as therapies for the treatment of human diseases.
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Human Mitochondrial Interactome during Neuronal Reprogramming
E.coli Membrane Complexes
Intergrated biological network of E.coli functional modules
Structural analysis of the E. coli binary interactome
Autophagy interaction network
Yeast Cell Envelope
Yeast Membrane Proteins Interaction Network
Overview of E. coli conjugation
Genetic / Functional redundancy between parallel pathways
Overview of the ESGA Process
Conservation of envelope bioprocess across bacterial species